Bioactivity | (Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist[1]. |
Name | (Rac)-LM11A-31 dihydrochloride |
CAS | 1214672-15-7 |
Formula | C12H27Cl2N3O2 |
Molar Mass | 316.27 |
Appearance | Oil |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
Reference | [1]. Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500. |