| Bioactivity | (Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide[1][2]. |
| Target | IC50: 0.073 µM (NEK 2), 8.0 μΜ (H929), 7.1 μΜ (AMOl), 8.7 μΜ (K12PE). |
| Name | (Rac)-CCT 250863 |
| CAS | 1364269-06-6 |
| Formula | C24H25F3N4O2S |
| Molar Mass | 490.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Innocenti P, et al. Design of potent and selective hybrid inhibitors of the mitotic kinase Nek2: structure-activity relationship, structural biology, and cellular activity. J Med Chem. 2012 Apr 12;55(7):3228-41. [2]. Ahsan A, et al. Methods for treating cancer with combination therapies. WO2021262962A1. |
(Rac)-CCT 250863
CAS: 1364269-06-6 F: C24H25F3N4O2S W: 490.54
(Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC50 of 0.073 µM. (Rac)-CCT 25
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