| Bioactivity | (Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent inhibitor of human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 10 nM and 68 nM, respectively. (Rac)-BMS-816336 has good metabolic stability[1]. | ||||||||||||
| Target | IC50: 10 nM (Human 11β-HSD1) and 68 nM (Mouse 11β-HSD1) | ||||||||||||
| In Vivo | (Rac)-BMS-816336 (compound 6n) has good metabolic stability, and the remaining rates in human, mouse and rats of 88%,82% and 72%, respectively[1]. | ||||||||||||
| Name | (Rac)-BMS-816336 | ||||||||||||
| Formula | C21H27NO3 | ||||||||||||
| Molar Mass | 341.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948. |