| Bioactivity | (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2]. | ||||||||||||
| Target | group I/group II mGluR | ||||||||||||
| Invitro | MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2]. | ||||||||||||
| In Vivo | (RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1]. Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2]. | ||||||||||||
| Name | (RS)-MCPG | ||||||||||||
| CAS | 146669-29-6 | ||||||||||||
| Formula | C10H11NO4 | ||||||||||||
| Molar Mass | 209.20 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Yang B et al. Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons. PLoS One, 2015 Sep 21, 10(9):e0138215. [2]. Fiona Yeuk-Lun Choi, et al. The effects of (RS)-MCPG on amphetamine-induced sensitization in neonatal rats. |
(RS)-MCPG
CAS: 146669-29-6 F: C10H11NO4 W: 209.20
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonis
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