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(RS)-Butyryltimolol

CAS: 2320274-78-8 F: C17H30N4O4S W: 386.51

(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the cor
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This product is for research use only, not for human use. We do not sell to patients.

Bioactivity (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2].
Invitro Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1].
Name (RS)-Butyryltimolol
CAS 2320274-78-8
Formula C17H30N4O4S
Molar Mass 386.51
Appearance Oil
Transport Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. [2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9.