Bioactivity | (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol[1]. Butyryltimolol is a β-adrenergic blocker[2]. | ||||||||||||
Invitro | Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1]. | ||||||||||||
Name | (RS)-Butyryltimolol | ||||||||||||
CAS | 2320274-78-8 | ||||||||||||
Formula | C17H30N4O4S | ||||||||||||
Molar Mass | 386.51 | ||||||||||||
Appearance | Oil | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
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Reference | [1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. [2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. |