(R,R)-BD-AcAc 2_product_DataBase

Bioactivity

(R,R)-BD-AcAc 2 ((R,R)-Ketone Ester), a ketone monoester, can be used as a source of oral nutritional ketones. (R,R)-BD-AcAc 2 can elevate plasma levels of β-hydroxybutyrate and acetoacetate, blood glucose, blood Na+ levels and blood creatinine levels after oral administration in mice. (R,R)-BD-AcAc 2 can partly prevent muscle weakness in septic mice. (R,R)-BD-AcAc 2 has potential to improve exercise performance and endurance in animal body. (R,R)-BD-AcAc 2 can also be used to research Parkinson’s disease or diabetes[1][2][3].

In Vivo

(R,R)-BD-AcAc 2 (D-3HHB) increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na+ levels and blood creatinine levels, and reduces plasma free fatty acid concentrations[1]. Animal Model:

Name

(R,R)-BD-AcAc 2

CAS

1208313-97-6

Formula

C8H16O4

Molar Mass

176.21

Appearance

Liquid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Weckx R, et al. Efficacy and safety of ketone ester infusion to prevent muscle weakness in a mouse model of sepsis-induced critical illness. Sci Rep. 2022 Jun 22;12(1):10591. [2]. Williams MS, et al. The Chemistry of the Ketogenic Diet: Updates and Opportunities in Organic Synthesis. Int J Mol Sci. 2021 May 15;22(10):5230. [3]. Clarke K, et al. Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate. Regul Toxicol Pharmacol. 2012 Jul;63(2):196-208.

PeptideDB

(R,R)-BD-AcAc 2

CAS: 1208313-97-6 F: C8H16O4 W: 176.21