(R)-Terazosin_product_DataBase

Bioactivity

(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent α1-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively[1].

Target

Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)

Invitro

(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 3.85 μM, 0.33 μM and 0.37 μM, respectively[1].(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies[1].

In Vivo

(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 7.5 and 5.31, respectively[1].

Name

(R)-Terazosin

CAS

109351-34-0

Formula

C19H25N5O4

Molar Mass

387.43

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15(7-8):863-85.

PeptideDB

(R)-Terazosin

CAS: 109351-34-0 F: C19H25N5O4 W: 387.43