| Bioactivity | (R)-SCH 42495 is the less active enantiomer of SCH 42495[1]. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[2]. |
| Invitro | NEP acts as a critical enzyme in the degradation. NEP cleaves atrial natriuretic factors (ANF) in vitro[1]. |
| In Vivo | Inhibition of NEP in vivo has been shown to produce beneficial vasodilatory and natriuretic responses[1]. |
| Name | (R)-SCH 42495 |
| CAS | 156792-25-5 |
| Formula | C20H29NO4S2 |
| Molar Mass | 411.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Neustadt BR, et al. Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives. J Med Chem. 1994 Jul 22;37(15):2461-76. [2]. Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. |
(R)-SCH 42495
CAS: 156792-25-5 F: C20H29NO4S2 W: 411.58
(R)-SCH 42495 is the less active enantiomer of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NE
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.