| Bioactivity | (R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (Ki: 14.8 μM; IC50: 65.5 μM). (R)-Phenylpiracetam can be used for the research of the neurological or neuropsychiatric disorders[1][2]. |
| Target | Ki: 14.8 μM (DAT); IC50: 65.5 μM (DAT) |
| Invitro | (R)-Phenylpiracetam displaces the binding of [125I] RTI-55 (IC50 = 4.82 μM) to human recombinant DAT expressed in CHO-K1 cells[2]. |
| In Vivo | (R)-Phenylpiracetam (50 mg/kg; p.o. or i.p.; single-dose) reaches the mouse brain tissue 15 min after administration[1].(R)-Phenylpiracetam (10, 25, 50 mg/kg; p.o.; pretreatment for 7 days) dose-dependently reduces paw oedema and the antinociceptive response on carrageenan induced mouse[1]. |
| Name | (R)-Phenylpiracetam |
| CAS | 949925-07-9 |
| Formula | C12H14N2O2 |
| Molar Mass | 218.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zvejniece L, et al. Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice. Inflammopharmacology. 2020;28(5):1283-1292. [2]. Sommer S, et al. The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats. Int J Neuropsychopharmacol. 2014;17(12):2045-2056. |
(R)-Phenylpiracetam
CAS: 949925-07-9 F: C12H14N2O2 W: 218.25
(R)-Phenylpiracetam (MRZ 9547) is a dopamine transporter (DAT) inhibitor (Ki: 14.8 μM; IC50: 65.5 μM). (R)-Phenylpirac
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