| Bioactivity | (R)-OY-101 is an orally active and specific inhibitor of P-gp. (R)-OY-101 increases tumor sensitivity to anticancer agents. (R)-OY-101 has good activity in reversing tumor resistance and promoting apoptosis and can be used in cancer related research[1]. |
| Invitro | (R)-OY-101 增加了长春新碱 (Vincristine；HY-N0488A) 对 Eca109/VCR 细胞的细胞毒性，IC50 值为 43.8 nM[1]。 |
| In Vivo | OY-101 在 SD 大鼠中的药代动力学 (PK) 参数[1]备注：(R)-OY-101 是 OY-101 的一种立体构型。Administration manner |
| Name | (R)-OY-101 |
| CAS | 23495-82-1 |
| Formula | C27H31NO4 |
| Molar Mass | 433.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zeng R, et al. Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy. J Med Chem. 2023 Mar 23;66(6):4086-4105. |