| Bioactivity | (R)-OP-1074 is the inactive isomer of OP-1074 (HY-125263), and can be used as an experimental control. OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2?nM, respectively[1]. |
| Name | (R)-OP-1074 |
| CAS | 1443752-77-9 |
| Formula | C29H31NO4 |
| Molar Mass | 457.56 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
| Reference | [1]. Fanning SW, et al. Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.Nat Commun. 2018 Jun 18;9(1):2368. |
(R)-OP-1074
CAS: 1443752-77-9 F: C29H31NO4 W: 457.56
(R)-OP-1074 is the inactive isomer of OP-1074 (HY-125263), and can be used as an experimental control. OP-1074 is a pure
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