| Bioactivity | (R)-NX-2127 (compound 28) is an orally active Bruton’s Tyrosine Kinase (Btk) degrader. (R)-NX-2127 degrades IKZF1 and IKZF3 by molecular glue interactions with the cereblon E3 ubiquitin ligase complex[1]. |
| CAS | 3024312-52-2 |
| Formula | C39H45N9O5 |
| Molar Mass | 719.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Robbins DW, et al. Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell Malignancies. J Med Chem. 2024 Feb 22;67(4):2321-2336. |
(R)-NX-2127
CAS: 3024312-52-2 F: C39H45N9O5 W: 719.83
(R)-NX-2127 (compound 28) is an orally active Bruton’s Tyrosine Kinase (Btk)degrader. (R)-NX-2127 degrades IKZF1 and IK
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.