| Bioactivity | (R)-MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. (R)-MDL-101146 inhibits HNE-induced hemorrhage in hamsters. (R)-MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1]. |
| CAS | 163660-53-5 |
| Formula | C29H37F5N4O6 |
| Molar Mass | 632.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Angelastro MR, et al. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. J Med Chem. 1994 Dec 23;37(26):4538-53. |
(R)-MDL-101146
CAS: 163660-53-5 F: C29H37F5N4O6 W: 632.62
(R)-MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a
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