| Bioactivity | (R)-LW-Srci-8 is a selective covalent inhibitor of c?Src (IC50= 35.83 nM) that disrupts the autophosphorylation of c?Src by targeting its autophosphorylation site (Y419)[1]. |
| Target | IC50: 35.83 (c?Src). |
| Invitro | MDA-MB-468 (5-20 μM; 3 h) 在 MDA-MB-468 细胞中以剂量依赖性抑制了 c-Src 在 Y419 处的磷酸化以及 STAT3 在 Y705 处的磷酸化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (R)-LW-Srci-8 相关抗体: |
| Formula | C19H22F2N2O2 |
| Molar Mass | 348.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang H, et al. Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS Chem Biol. 2024;19(4):999-1010. |