| Bioactivity | (R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.35 μM and 3.3 μM, respectively. (R)-Indeloxazine benzenesulfonate (AS1069562) possesses curative-like analgesic effect. (R)-Indeloxazine benzenesulfonate (AS1069562) might improve nerve function impairment via the amelioration of neurotrophic support[1][2]. |
| In Vivo | (R)-Indeloxazine benzenesulfonate (AS1069562, STZ-induced diabetic rats, orally, 3, 10, and 30 mg/kg) 在 Streptozotocin (STZ, HY-13753) 诱导的糖尿病神经性疼痛大鼠模型中给药 4 周具有持久的镇痛效果[2]。(R)-Indeloxazine benzenesulfonate (AS1069562, STZ-induced diabetic rats, orally, 3, 10, and 30 mg/kg) 显著恢复背根神经节和脊髓中下降的 IGF1 和 IGF2 mRNA 水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1623762-83-3 |
| Formula | C20H23NO5S |
| Molar Mass | 389.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nobuhito Murai, et al. AS1069562, the (+)-isomer of indeloxazine, exerts analgesic effects in a rat model of neuropathic pain with unique characteristics in spinal monoamine turnover. J Pharmacol Exp Ther. 2014 Mar;348(3):372-82. [2]. Nobuhito Murai, et al. AS1069562, the (+)-isomer of indeloxazine, but not duloxetine has a curative-like analgesic effect in a rat model of streptozotocin-induced diabetic neuropathy. Neuropharmacology. 2014 Apr:79:10-6. |
(R)-Indeloxazine benzenesulfonate
CAS: 1623762-83-3 F: C20H23NO5S W: 389.47
(R)-Indeloxazine benzenesulfonate (AS1069562) is an orally active 5-HT and NE reuptake inhibitor, with IC50 values of 0.
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