(R)-G12Di-7_product_DataBase

Bioactivity	(R)-G12Di-7 is a covalent ligand for KRAS-G12D, which selectively labels K-Ras-G12D·GDP and K-Ras-G12D·GppNHp. (R)-G12Di-7 exhibits inhibitory activity against G12D mutated cancer cells[1].
Invitro	(R)-G12Di-7 (1-100 nM) 抑制 KRAS-G12D 突变细胞 Ba/F3、SW1990、AsPC-1 和 AGS 的细胞活力，GI50s 分别为 73 nM，409 nM，467 nM 和 109 nM[1]。(R)-G12Di-7 (10 μM) 在 G12D 突变细胞 Ba/F3、SW1990、AsPC-1 和 AGS 中标记 KRAS-G12D，从而抑制下游信号传导，并且在 12 小时之内保持稳定性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (R)-G12Di-7 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	(R)-G12Di-7 (10-50 mg/kg，腹腔注射，一天两次共 28 天) 在 SW1900 异种移植 NOD/SCID 小鼠体内具有抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2946593-60-6
Formula	C39H37F3N6O5
Molar Mass	726.74
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zheng Q, et al., Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D. Nat Chem Biol. 2024 Mar 5.

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