| Bioactivity | (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1]. |
| Name | (R)-DRF053 dihydrochloride |
| CAS | 1241675-76-2 |
| Formula | C23H29Cl2N7O |
| Molar Mass | 490.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nassima Oumata, et al. Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. J Med Chem. 2008 Sep 11;51(17):5229-42. |
(R)-DRF053 dihydrochloride
CAS: 1241675-76-2 F: C23H29Cl2N7O W: 490.43
(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM,
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