| Bioactivity | (R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer[1]. | ||||||||||||
| CAS | 1655527-68-6 | ||||||||||||
| Formula | C20H27ClN6O | ||||||||||||
| Molar Mass | 402.92 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lawrence H R, et al. Development of novel ACK1/TNK2 inhibitors using a fragment-based approach[J]. Journal of medicinal chemistry, 2015, 58(6): 2746-2763. |