| Bioactivity | (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1]. |
| Invitro | (Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1].(Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1].(Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1].(Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1]. |
| Name | (Nle4)-α-MSH |
| CAS | 64887-70-3 |
| Shortening | Ac-SYS-{Nle}-EHFRWGKPV-NH2 |
| Formula | C78H111N21O19 |
| Molar Mass | 1646.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
(Nle4)-α-MSH
CAS: 64887-70-3 F: C78H111N21O19 W: 1646.85
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly d
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