| Bioactivity | (E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antiproliferative effect[1][2]. |
| Name | (E/Z)-THZ1 dihydrochloride |
| CAS | 2095433-94-4 |
| Formula | C31H30Cl3N7O2 |
| Molar Mass | 638.97 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014;511(7511):616-620. [2]. Nilson KA, et al. THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping and Pausing. Mol Cell. 2015;59(4):576-587. |
(E/Z)-THZ1 dihydrochloride
CAS: 2095433-94-4 F: C31H30Cl3N7O2 W: 638.97
(E/Z)-THZ1 dihydrochloride is a selective inhibitor of CDK7 with an IC50 of 3.2 nM. (E/Z)-THZ1 dihydrochloride has antip
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