| Bioactivity | E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway[1]. |
| In Vivo | E/Z-SIS3 free base (2 mg/kg，腹腔注射) 抑制 smad3 磷酸化和 TGF-β1 水平，改善 C57BL/6J 小鼠中博来霉素 (BLM) 诱导的肺纤维化 (PF) 和炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1009104-85-1 |
| Formula | C28H27N3O3 |
| Molar Mass | 453.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shou J, et al., SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2018 Sep 5;503(2):757-762. |
(E/Z)-SIS3 free base
CAS: 1009104-85-1 F: C28H27N3O3 W: 453.53
E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.