| Bioactivity | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) can be used for growth and development regulation[1][2]. | ||||||
| Invitro | (D-Trp12,Tyr34)-pTH (7-34) amide (0.05-10 μM) causes a concentration-dependent inhibition of PTHrP or PTH-stimulated cAMP formation in opossum kidney (OK) cells[2].(D-Trp12,Tyr34)-pTH (7-34) amide (0.1-10 μM) attenuates inhibition of NapiT promoted by 1 nM of either PTHrP or PTH[2]. | ||||||
| Name | (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) | ||||||
| CAS | 118102-98-0 | ||||||
| Sequence | Phe-Met-His-Asn-Leu-{d-Trp}-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2 | ||||||
| Shortening | FMHNL-{d-Trp}-KHLSSMERVEWLRKKLQDVHNY-NH2 | ||||||
| Formula | C165H251N49O40S2 | ||||||
| Molar Mass | 3625.25 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine)
CAS: 118102-98-0 F: C165H251N49O40S2 W: 3625.25
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki
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