| Bioactivity | (D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R[1]. |
| Name | (D-Arg8)-Inotocin |
| CAS | 745816-74-4 |
| Sequence | Cys-Leu-Ile-Thr-Asn-Cys-Pro-{d-Arg}-Gly-NH2 (Disulfide bridge: Cys1-Cys6) |
| Shortening | CLITNCP-{d-Arg}-G-NH2 (Disulfide bridge: Cys1-Cys6) |
| Formula | C39H68N14O11S2 |
| Molar Mass | 973.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Giglio MGD, et, al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Sci Rep. 2017 Feb 1;7:41002. |
(D-Arg8)-Inotocin
CAS: 745816-74-4 F: C39H68N14O11S2 W: 973.17
(D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM.
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