| Bioactivity | (D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1]. |
| Invitro | (D)-PPA 1 (0.2 mg/mL, 1.0 mg/mL) 在 1.0 mg/mL 时阻断 PD-1/PD-L1 之间的相互作用[1]。(d) -ppa 1 (3.125-100 μM;24 h, 48 h) 不直接杀死肿瘤细胞，对 CT26 细胞生长无影响[1]。 Cell Viability Assay[1] Cell Line: |
| Name | (D)-PPA 1 |
| CAS | 1620813-53-7 |
| Sequence | D-{Asn-Tyr-Ser-Lys-Pro-Thr-Asp-Arg-Gln-Tyr-His-Phe} |
| Shortening | D-{NYSKPTDRQYHF} |
| Formula | C70H98N20O21 |
| Molar Mass | 1555.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
(D)-PPA 1
CAS: 1620813-53-7 F: C70H98N20O21 W: 1555.65
(D)-PPA 1 is a hydrolysisresistant d-peptide antagonist. (D)-PPA 1 serves as a potent PD-1/PD-L1 inhibitor. (D)-PPA 1 bi
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