| Bioactivity | (2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1]. | ||||||||||||
| Invitro | Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1]. | ||||||||||||
| Name | (2S,3S)-E1R | ||||||||||||
| CAS | 1424832-57-4 | ||||||||||||
| Formula | C13H16N2O2 | ||||||||||||
| Molar Mass | 232.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71. |
(2S,3S)-E1R
CAS: 1424832-57-4 F: C13H16N2O2 W: 232.28
(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1
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