| Bioactivity | (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1]. |
| Invitro | (2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1]. |
| Name | (2S,3R)-LP99 |
| CAS | 1808948-28-8 |
| Formula | C26H30ClN3O4S |
| Molar Mass | 516.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21. |
(2S,3R)-LP99
CAS: 1808948-28-8 F: C26H30ClN3O4S W: 516.05
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the a
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