(25S)-Δ7-Dafachronic acid_product_DataBase

Bioactivity	(25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans[1][2][3].
Invitro	在使用 HEK-293 细胞进行的 Gal4 反式激活测定中，(25S)-Δ7-Dafachronic Acid 是一种有效的转录激活剂 (EC50: 33 nM)[2]。(25S)-Δ7-Dafachronic Acid (10 μM，48 小时) 刺激幼虫生长和发育[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (25S)-Δ7-Dafachronic acid 相关抗体:
CAS	949004-12-0
Formula	C27H42O3
Molar Mass	414.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. [2]. Martin R,et al. Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid. Org Biomol Chem. 2008 Dec 7;6(23):4293-5. [3]. Sharma KK, et al. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol. 2009 May;23(5):640-8. [4]. Ma G, et al. Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism. PLoS Pathog. 2019 Jul 23;15(7):e1007960.

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