| Bioactivity | 24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR). 24S,25-Epoxycholesterol exhibits properties in regulating the cholesterol efflux[1], inhibiting tumor growth against gastric cancer and glioblastoma[2][3] and inducing apoptosis in BMMC cells[5]. |
| Invitro | 24S,25-Epoxycholesterol (1-10 μM) 上调 LXR 相关基因 ABCA1、ABCG1 和 APOE，促进胆固醇流出，从而防止泡沫细胞形成，并通过消除细胞胆固醇来阻止小鼠和人类神经胶质瘤干细胞的增殖[1][3]。24S,25-Epoxycholesterol 抑制 HGC27 的增殖和迁移，敲除 LXRβ 可增强这种增殖和迁移[2]。24S,25-Epoxycholesterol (40 μM) 抑制 HMG-CoA 还原酶并激活 LXR，从而抑制甲羟戊酸 (mevalonate) 依赖性类异戊二烯 (isoprenoid) 的生成并增强 ATP 结合盒转运蛋白 G1 表达，诱导骨髓源性小鼠肥大细胞 (BMMC) 凋亡[5]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (24S,25)-Epoxycholesterol 相关抗体: Cell Proliferation Assay[2] Cell Line: |
| In Vivo | 24S,25-Epoxycholesterol (5 mM，脑室注射) 可增强 CYP46A1 过表达小鼠中脑的中脑多巴胺神经元 (mDA) 神经发生、限制神经变性[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 77058-74-3 |
| Formula | C27H44O2 |
| Molar Mass | 400.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Beyea MM, et al., Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol. J Biol Chem. 2007 Feb 23;282(8):5207-16. [2]. Guo F, et al., Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells. Biochem Biophys Res Commun. 2018 Oct 12;504(4):892-898. [3]. Nguyen TP, et al., Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. [4]. Theofilopoulos S, et al., 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. J Biol Chem. 2019 Mar 15;294(11):4169-4176. [5]. Fukunaga M, et al., Mast cell death induced by 24(S),25-epoxycholesterol. Exp Cell Res. 2010 Nov 15;316(19):3272-81. |
(24S,25)-Epoxycholesterol
CAS: 77058-74-3 F: C27H44O2 W: 400.64
24S,25-Epoxycholesterol is an agonist for Liver X Receptor (LXR). 24S,25-Epoxycholesterol exhibits properties in regulat
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