| Bioactivity | (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyethoxy)acetic acid is a reliable and sensitive shortterm biomarker in urine[1]. |
| Invitro | (2-Hydroxyethoxy)acetic acid (HEAA) exists in a pH-dependent equilibrium with the cyclic lactone dioxan-2-one, whereby the open-chain form of (2-Hydroxyethoxy)acetic acid is found to be stable under acidic conditions[1]. |
| In Vivo | The main metabolic pathway of 1,4-Dioxane is oxidized by cytochrome P450 monooxygenase to (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid; HEAA), which is then rapidly excreted in urine[1]. |
| Name | (2-Hydroxyethoxy)acetic acid |
| CAS | 13382-47-3 |
| Formula | C4H8O4 |
| Molar Mass | 120.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elisabeth Eckert, et al. Reliable quantitation of β-hydroxyethoxyacetic acid in human urine by an isotope-dilution GC-MS procedure. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 15;935:80-4. |
(2-Hydroxyethoxy)acetic acid
CAS: 13382-47-3 F: C4H8O4 W: 120.10
(2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the main urinary metabolite of 1,4-Dioxane. (2-Hydroxyetho
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