| Bioactivity | (1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC50 value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity[1]. |
| Invitro | (1R,3S)-THCCA-Asn (4j) (0.001-500 μM) has anti-platelet aggregation activity with the IC50 value ranged from 0.07 μM to 0.14 μM, and inhibits ADP-induced platelet aggregation by less than 20% as well as AA-induced platelet aggregation by less than 10%[1].(1R,3S)-THCCA-Asn (4j) (0.001-1000 μM, 48 h) has less toxic to mammalian cells such as liver cell, colon mucosa cell and human dermal fibroblasts in vitro[1]. Cell Proliferation Assay[1] Cell Line: |
| In Vivo | (1R,3S)-THCCA-Asn (4j) (p.o., 0.001-1 nM/kg) can act against thrombosis of rats in a dose-dependent manner with no toxic side effects[1]. Animal Model: |
| Name | (1R,3S)-THCCA-Asn |
| Formula | C24H24N4O6 |
| Molar Mass | 464.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiaoyi Zhang, et al. (1R,3S)-THCCA-Asn: To show the discovery of selective inhibitor of thrombin by successfully combining virtual screening and biological assay,European Journal of Medicinal Chemistry,Volume 242,2022,114681. |