| Bioactivity | (-)BI97D6 is a broad-spectrum inhibitor of the Bcl-2 protein family, inhibiting Mcl-1, Bcl-2, Bcl-xL and Bcl-1 with IC50 values of 0.025, 0.031, 0.076 and 0.122 μM, respectively. (-)BI97D6 stimulates cell death through the Bak and Bax mediated mitochondrial apoptosis pathway. In addition, (-)BI97D6 inhibits Mcl-1 and can effectively induce apoptosis in acute myeloid leukemia (AML) cells[1]. |
| CAS | 1430067-36-9 |
| Formula | C36H26O8 |
| Molar Mass | 586.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rongqing Pan, et al. "Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–) BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia." Blood, The Journal of the American Society of Hematology 126.3 (2015): 363-372. |