| Bioactivity | (-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1]. |
| Invitro | (−)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs[1].(−)-zuonin A inhibits the activation and phosphorylation of JNK by MKK4 and MKK7[1]. |
| Name | (-)-Zuonin A |
| CAS | 84709-25-1 |
| Formula | C20H20O5 |
| Molar Mass | 340.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |