| Bioactivity | (-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalol can be used for the research of cardiac arrhythmias[1]. | ||||||||||||
| Target | Kd: 0.60 μM (hERG) | ||||||||||||
| Invitro | (-)-Sotalol (30-1000 μM) inhibits hERG current in HEK-293 cells, with an IC50 of 288 μM[1]. | ||||||||||||
| Name | (-)-Sotalol | ||||||||||||
| CAS | 30236-31-8 | ||||||||||||
| Formula | C12H20N2O3S | ||||||||||||
| Molar Mass | 272.36 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. DeMarco KR, et, al. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. J Mol Cell Cardiol. 2021 Sep;158:163-177. |
(-)-Sotalol
CAS: 30236-31-8 F: C12H20N2O3S W: 272.36
(-)-Sotalol ((R)-Sotalol) is the R-isomer of Sotalol. (-)-Sotalol is a hERG inhibitor, with a Kd of 0.60 μM. (-)-Sotalo
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