(-)-Pinoresinol 4-O-glucoside_product_DataBase

Bioactivity	(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].
Target	IC50: 48.13 µM (α-Glucosidase)
Invitro	(-)-Pinoresinol 4-O-glucoside (0、10、30 µM；24 小时) 在含有 50 μg/mL 的成骨补充培养基 (OS) 中增加前成骨细胞分化过程中的细胞迁移[1].(-)-Pinoresinol 4-O-glucoside (10、30 µM；7 天) 在前成骨细胞分化过程中增加早期分化并增加矿化结节的形成[1]。(-)-Pinoresinol 4-O-glucoside (10、30 µM；3 天) 增加前成骨细胞中 BMP2、ALP、OCN mRNA 水平的表达[1]。(-)-Pinoresinol 4-O-glucoside (10、30 µM；3 天) 增加 BMP2、p-Smad1/5/8、RUNX2 的蛋白表达水平[1]。 RT-PCR[1] Cell Line:
In Vivo	(-)-Pinoresinol 4-O-glucoside (50 mg/kg；口服；20 天) 减轻小鼠的氧化应激、高血糖和肝毒性[2]。 Animal Model:
Name	(-)-Pinoresinol 4-O-glucoside
CAS	41607-20-9
Formula	C26H32O11
Molar Mass	520.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. [2]. Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839.

PeptideDB

(-)-Pinoresinol 4-O-glucoside

CAS: 41607-20-9 F: C26H32O11 W: 520.53