| Bioactivity | (-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-)-pimobedan from erythrocytes is significantly lower than that of (+)-pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-)-pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+)-isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-)-pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use. |
| CAS | 118428-37-8 |
| Formula | C19H18N4O2 |
| Molar Mass | 334.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Plasma and red blood cell pharmacokinetics of pimobendan enantiomers in healthy Chinese |
(-)-Pimobendan
CAS: 118428-37-8 F: C19H18N4O2 W: 334.37
(-)-Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into e
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