| Bioactivity | (-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. |
| Target | EC50: 18 nM (FXR in FRET assay), 29 nM (FXR in M1H assay) |
| Name | (-)-PX20606 trans isomer |
| CAS | 1268244-88-7 |
| Formula | C29H22Cl3NO4 |
| Molar Mass | 554.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. |
(-)-PX20606 trans isomer
CAS: 1268244-88-7 F: C29H22Cl3NO4 W: 554.85
(-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
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