| Bioactivity | (-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide[1]. |
| CAS | 54325-07-4 |
| Formula | C19H19NO4 |
| Molar Mass | 325.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study |
(-)-Domesticine
CAS: 54325-07-4 F: C19H19NO4 W: 325.36
(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS c
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