| Bioactivity | (-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM. | ||||||||||||
| Target | EC50: 237 μM (GABA receptor) | ||||||||||||
| Invitro | (-)-Borneol is an enantiomer of (+)-Borneol. (+)-Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. At high concentrations (>1.5 mM), (-)-Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (-)-Borneol produces dose-dependent positive modulation of the Cl- conductance generated by extremely low dose GABA at α1β2γ2L GABAA receptors[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (-)-Borneol 相关抗体: | ||||||||||||
| CAS | 464-45-9 | ||||||||||||
| Formula | C10H18O | ||||||||||||
| Molar Mass | 154.25 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. IGranger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11. |