Bioactivity | (-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research[1]. |
CAS | 2104810-16-2 |
Formula | C19H23ClFNO2 |
Molar Mass | 351.84 |
Appearance | 固体 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Reference | [1]. Guiping Zhang, et al. "Discovery of N-substituted (2-phenylcyclopropyl) methylamines as functionally selective serotonin 2C receptor agonists for potential use as antipsychotic medications." Journal of medicinal chemistry 60.14 (2017): 6273-6288. |