| Bioactivity | (+)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1][2]. | ||||||||||||
| Invitro | (+)-TK216 (compound 13; for 3 days) has an IC50>5 μM in SKES cells (Ewing Sarcoma cell line)[1]. (+)-TK216 has T1/2s of 103.4 mins, 3.6 mins, 26.6 mins and 8.4 mins for human, rat, mouse, dog liver microsomes[1]. | ||||||||||||
| Name | (+)-TK216 | ||||||||||||
| CAS | 1903783-77-6 | ||||||||||||
| Formula | C19H15Cl2NO3 | ||||||||||||
| Molar Mass | 376.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176. [2]. Jean-Michael Vernier, et al. Indolinone compounds and uses thereof. WO2016057698A1. |
(+)-TK216
CAS: 1903783-77-6 F: C19H15Cl2NO3 W: 376.23
(+)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS)
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