| Bioactivity | (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. |
| Target | AChR |
| Invitro | (+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1]. |
| Name | (+)-Sparteine |
| CAS | 492-08-0 |
| Formula | C15H26N2 |
| Molar Mass | 234.38 |
| Appearance | Liquid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5. |
(+)-Sparteine
CAS: 492-08-0 F: C15H26N2 W: 234.38
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic
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