| Bioactivity | (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1]. |
| Invitro | (+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively[1]. |
| Name | (+)-SHIN1 |
| CAS | 2443966-90-1 |
| Formula | C24H24N4O2 |
| Molar Mass | 400.47 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
| Reference | [1]. Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. |