| Bioactivity | (+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2]. | ||||||||||||
| Target | IC50: 0.74 μM (β-adrenoceptor). | ||||||||||||
| Invitro | (+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2]. | ||||||||||||
| Name | (+)-Penbutolol | ||||||||||||
| CAS | 38363-41-6 | ||||||||||||
| Formula | C18H29NO2 | ||||||||||||
| Molar Mass | 291.43 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8. |
(+)-Penbutolol
CAS: 38363-41-6 F: C18H29NO2 W: 291.43
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbu
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.