| Bioactivity | (+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a benzyl prolinate and a enantiomer of KCC2 blocker 1[1]. |
| Target | IC50: 0.4 μM (KCC2) |
| Invitro | (+)-KCC2 blocker 1 ((+)-13), a enantiomers of KCC2 blocker 1, has a 100-fold difference in potency compare with enantiomer (-)-KCC2 blocker 1 ((−)-13))[1]. |
| Name | (+)-KCC2 blocker 1 |
| CAS | 1228439-71-1 |
| Formula | C22H25NO5S |
| Molar Mass | 415.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pégurier C, et al. Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2542-5. |
(+)-KCC2 blocker 1
CAS: 1228439-71-1 F: C22H25NO5S W: 415.50
(+)-KCC2 blocker 1 is a selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 0.4 μM. (+)-KCC2 blocker 1 is a ben
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