| CAS | 140678-12-2 |
| Sequence | H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Arg-Lys-Cys-Lys-Asp-Arg-Arg-Cys-Lys-Hyp-Met-Lys-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/Cys10 and Cys21) |
| Sequence Single | RDCCT-Hyp-Hyp-RKCKDRRCK-Hyp-MKCCA-NH2 |
| Molecular Formula | C101H175N39O30S7 |
| Molecular Weight | 2640.21 |
| Synonyms | Geographutoxin II (GTXII) |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | µ-Conotoxin GIIIB also called Geographutoxin II (GTXII), is a strongly basic peptide from the venom of Conus geographus, it is highly effective in blocking sodium channels in vertebrate skeletal muscle, thereby preventing the propagation of muscle action potentials. |
| References | 1. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. C.M.Haynes et al., Dev. Cell, 13, 467 (2007) 2. Solution synthesis of mu-conotoxin GIIIB: optimization of the oxidative folding reaction. L.J.Cruz et al., J. Toxicol. Toxin Rev., 4, 107 (1985) 3. Use of geographutoxin II (mu-conotoxin) for the study of neuromuscular transmission in mouse. S.Kubo et al., Pept. Res., 6, 66 (1993) 4. Peptide toxins from venomous Conus snails. S.J.Hong and C.C.Chang, Br. J. Pharmacol., 97, 934 (1989) |