| CAS | 106375-28-4 |
| Sequence | H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bonds between Cys1 and Cys16/Cys8 and Cys19/ Cys15 and Cys26) |
| Sequence Single | CKSGSSCSTSYNCCRSCNYTKRCY-NH2 |
| Molecular Formula | C120H182N38O43S6 |
| Molecular Weight | 3037.39 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | ω-Conotoxin GVIA is a peptide from the venom of the fish-hunting cone snail Conus geographus, it can efficiently blocks neuronal calcium channels. This presynaptic inhibition of calcium influx prevents the voltage-activated release of acetylcholine. |
| References | 1. The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. A.Inoue et al., Proc. Natl. Acad. Sci. USA, 86, 2863 (1989) 2. Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. K.Sato et al., Biochem. Biophys. Res. Commun., 194, 1292 (1993) 3. Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes. J.Rivier et al., J. Biol. Chem., 262, 1194 (1987) 4. Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. B.M.Olivera et al., Biochemistry, 23, 5087 (1984) 5. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. B.M.Olivera et al., Biochemistry, 26, 2086 (1987) 6. Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes. J.R.Abbott and M.J.Litzinger, Int. J. Devl Neurosci., 12, 43 (1994) 7. Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. Ya-Kun Cao, et al. Hypertens Res. 2020 Aug;43(8):765-771. |