| CAS | 129129-65-3 |
| Sequence | H-Arg-Asp-Cys-Cys-Thr-Hyp-Hyp-Lys-Lys-Cys-Lys-Asp-Arg-Gln-Cys-Lys-Hyp-Gln-Arg-Cys-Cys-Ala-NH2 (Disulfide bonds between Cys3 and Cys15/Cys4 and Cys20/Cys10 and Cys21) |
| Sequence Single | RDCCT-Hyp-Hyp-KKCKDRQCK-Hyp-QRCCA-NH2 |
| Molecular Formula | C100H170N38O32S6 |
| Molecular Weight | 2609.08 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | µ-Conotoxin GIIIA is a peptide isolated from the Conus geographus L. venom, it blocks with very high selectivity the muscle subtype of sodium channels. |
| References | 1. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels. D.R.Hillyard et al., Neuron, 9, 69 (1992) 2. Conus geographus toxins that discriminate between neuronal and muscle sodium channels. L.J.Cruz et al., J. Biol. Chem., 260, 9280 (1985) 3. mu-conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling, and receptor characterization. L.J.Cruz et al., Biochemistry, 28, 3437 (1989) |