| CAS | 88217-10-1 |
| Sequence | H-Gly-Arg-Cys-Cys-His-Pro-Ala-Cys-Gly-Lys-Asn-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys3 and Cys8/Cys4 and Cys14) |
| Sequence Single | GRCCHPACGKNYSC |
| Molecular Formula | C58H88N22O17S4 |
| Molecular Weight | 1493.74 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Application | Ion Channel Modulating Agents |
| Description | α-Conotoxin MI has been isolated from the venom of the sea snail Conus imperialis. The conotoxin is a ligand for nicotinic acetylcholine receptors. It is highly active against the neuromuscular receptor in frogs but not in mice. α-Conotoxin MI is a potent and selective inhibitor of mAChR and α1β1γδ nAChR, but has no effect on nicotine-stimulated dopamine release. α-Conotoxins are small, disulfide-rich peptides that competitively inhibit muscle and neuronal nicotinic AChRs. |
| References | 1. [3H]-[Thr4,Gly7]OT: a highly selective ligand for central and peripheral OT receptors. J.Elands et al., Am. J. Physiol., 254, E31 (1988) 2. A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI. J.M.McIntosh et al., J. Biol. Chem., 269, 16733 (1994) 3. alpha-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses. R.W.Janes, Curr. Opin. Pharmacol., 5, 280 (2006) 4. Alpha-conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. Kulak JM, et al. J Neurosci. 1997 Jul 15;17(14):5263-70. 5. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site. Bren N, et al. J Biol Chem. 2000 Apr 28;275(17):12692-700. |