| CAS | 187389-52-2 |
| Sequence | Z-Val-Ala-Asp(OMe)-FMK |
| Sequence Single | Z-VAD(OMe)-FMK |
| Molecular Formula | C22H30FN3O7 |
| Molecular Weight | 467.49 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | Z-VAD-FMK also called Z-VAD(OMe)-FMK, is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. |
| References | 1. Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Slee et al (1996). Biochem.J. 315 21 PMID: 8670109 2. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Kunstle et al (1997). Immunol.Lett. 55 5 PMID: 9093874 3. Inhibition of human caspases by peptide-based and macromolecular inhibitors. Garcia-Calvo et al (1998). J.Biol.Chem. 273 32608 PMID: 9829999 4. Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. King et al (1998). Leukemia 12 1553 PMID: 9766499 |