| CAS | 130408-77-4 |
| Sequence | Boc-Trp-Lys(Tac)-Asp-N(Me)Phe-NH2 |
| Sequence Single | Boc-WK(Tac)-D-N-Me-F-NH2 |
| Molecular Formula | C44H56N8O9 |
| Molecular Weight | 840.97 |
| Technology | Synthetic |
| Storage | -20°C, avoid light, cool and dry place |
| Description | A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively. |
| References | 1. A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Asin et al (1992). Pharmacol.Biochem.Behav. 42 699 PMID: 1513850 2. Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors. C W Lin, et al. Mol Pharmacol. 1991 Mar;39(3):346-51. 3. Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats. K E Asin, et al. Brain Res. 1992 Jan 31;571(1):169-74. 4. Cholecystokinin 1 Receptor (Cck1R) Activates mTORC1 signaling and is Protective to Purkinje cells in SCA Mice. Emily A.L. Wozniak, et al. bioRxiv. February 17, 2021. |